B7-33
Relaxin-2 Analog | Anti-Fibrotic & Cardiovascular
B7-33 is a single-chain peptide analog of human relaxin-2 that selectively activates the relaxin family peptide receptor 1 (RXFP1). Unlike native relaxin-2, which requires a complex two-chain A/B structure connected by disulfide bonds, B7-33 achieves RXFP1 activation with a much simpler single-chain design. This makes it significantly easier and more cost-effective to synthesize. Preclinical research demonstrates potent anti-fibrotic, vasodilatory, and cardioprotective properties, positioning B7-33 as a promising therapeutic candidate for fibrotic diseases, heart failure, and vascular dysfunction.
Moleküler Gösterim
M.W.: ~4,000 Da
PubChem 2D yapı diyagramı
Referans Flakon
Referans illüstrasyonu — ürün listesi değildir
Etki Mekanizması
Selectively activates RXFP1, the primary receptor for relaxin-2, triggering downstream signaling cascades that inhibit fibroblast activation and collagen deposition, promote extracellular matrix remodeling via increased matrix metalloproteinase (MMP) activity, enhance nitric oxide-mediated vasodilation, and reduce inflammatory cytokine expression. B7-33 appears to preferentially engage pERK1/2 signaling pathways while showing reduced cAMP activation compared to native relaxin-2, suggesting biased agonism at RXFP1.
B7-33 is a single-chain peptide analog of human relaxin-2 that selectively activates the relaxin family peptide receptor 1 (RXFP1). Unlike native relaxin-2, which requires a complex two-chain A/B structure connected by disulfide bonds, B7-33 achieves RXFP1 activation with a much simpler single-chain design. This makes it significantly easier and more cost-effective to synthesize. Preclinical research demonstrates potent anti-fibrotic, vasodilatory, and cardioprotective properties, positioning B7-33 as a promising therapeutic candidate for fibrotic diseases, heart failure, and vascular dysfunction.
Moleküler Veri
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Doz Protokolleri
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| Hedef | Doz | Sıklık | Yol |
|---|---|---|---|
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Telmisartan
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BPC-157
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Kaynaklar
- A single-chain peptide derived from the relaxin B-chain selectively activates RXFP1 — Hossain, M.A., et al.
- The single-chain relaxin mimetic, B7-33, maintains anti-fibrotic activity in liver and kidney fibrosis models — Hossain, M.A., et al.
- The relaxin receptor as a therapeutic target -- perspectives from evolution and drug targeting — Bathgate, R.A.D., et al.
- B7-33 replicates the vasoprotective effects of relaxin in mouse models of cardiovascular disease — Marshall, S.A., et al.
- The role of relaxin and its receptor (RXFP1) in the pathogenesis and treatment of fibrotic diseases — Samuel, C.S., et al.