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Teriparatide

PTH(1-34) | Bone-Building Anabolic Peptide

Teriparatide is an FDA-approved anabolic bone-building agent consisting of the first 34 amino acids of parathyroid hormone. Unlike antiresorptive osteoporosis drugs that slow bone loss, teriparatide actively stimulates new bone formation. The key to its mechanism is intermittent exposure: while continuous PTH causes bone resorption, daily injections stimulate osteoblasts more than osteoclasts, resulting in net bone formation. Clinical trials show 8% spine bone density increases and 65% reduction in vertebral fractures.

Yarı ömür
~1 hour (subcutaneous); ~5 minutes (intravenous)
Sıklık
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Döngü
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Doz
20mcg daily (FDA-approved dose)

Moleküler Gösterim

Teriparatide 2D chemical structure

M.W.: 4,118 Da

PubChem 2D yapı diyagramı

Referans Flakon

DEEP ARCHIVESUPPLEMENTTeriparatidePTH(1-34) | Bone-Building …PURITY: 99% HPLCRUO: Research Use OnlyREF TER-446-DSAM.W. 4,118 DaNOT FOR HUMAN OR VETERINARY USE

Referans illüstrasyonu — ürün listesi değildir

Etki Mekanizması

Teriparatide binds to PTH type 1 receptors (G-protein coupled receptors) on osteoblasts, osteocytes, and renal tubular cells. This activates PKA and PKC signaling pathways that promote osteoblast activity. The intermittent daily dosing creates an 'anabolic window' where bone formation exceeds resorption. Teriparatide upregulates IGF-1 and FGF2 expression, stimulates bone formation on trabecular and cortical surfaces, and increases bone mineral density through preferential osteoblast stimulation.

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Teriparatide is an FDA-approved anabolic bone-building agent consisting of the first 34 amino acids of parathyroid hormone. Unlike antiresorptive osteoporosis drugs that slow bone loss, teriparatide actively stimulates new bone formation. The key to its mechanism is intermittent exposure: while continuous PTH causes bone resorption, daily injections stimulate osteoblasts more than osteoclasts, resulting in net bone formation. Clinical trials show 8% spine bone density increases and 65% reduction in vertebral fractures.

Moleküler Veri

Tür
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Moleküler ağırlık
4,118 Da

1000 mcg = 1 mg

1 = her gün · 7 = haftalık

Süre (gün)

Araştırma Endikasyonları

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most effective

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most effective

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effective

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moderate

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Doz Protokolleri

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Etkileşimler

+
Bisphosphonates
compatible

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++
Calcium/Vitamin D
synergistic

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+
BPC-157
compatible

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+
TB-500
compatible

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