Orforglipron
Oral Small-Molecule GLP-1 Receptor Agonist | Weight Loss & Diabetes
First oral non-peptide GLP-1 completing Phase 3 trials. Achieves substantial weight loss without injections, refrigeration, or dietary restrictions, with clinical evidence of 12.4% weight reduction at 72 weeks.
Moleküler Gösterim
M.W.: 882.974 Da
PubChem 2D yapı diyagramı
Referans Flakon
Referans illüstrasyonu — ürün listesi değildir
Etki Mekanizması
Small-molecule GLP-1 receptor agonist with biased signaling preferentially activating G protein/cAMP pathways, enhancing insulin secretion, suppressing glucagon, delaying gastric emptying, and reducing appetite while minimizing receptor desensitization. 79.1% oral bioavailability with 29-49 hour half-life.
First oral non-peptide GLP-1 completing Phase 3 trials. Achieves substantial weight loss without injections, refrigeration, or dietary restrictions, with clinical evidence of 12.4% weight reduction at 72 weeks.
Moleküler Veri
Araştırma Endikasyonları
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Doz Protokolleri
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| Hedef | Doz | Sıklık | Yol |
|---|---|---|---|
| MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 35 MINUTES 02 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE | 3mg daily | MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 35 MINUTES 02 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE | MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 52 MINUTES 54 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE |
| MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 35 MINUTES 02 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE | 12mg daily | MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 35 MINUTES 02 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE | MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 52 MINUTES 54 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE |
| MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 35 MINUTES 02 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE | 36mg daily | MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 35 MINUTES 02 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE | MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 52 MINUTES 54 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE |
| MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 35 MINUTES 02 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE | 6mg daily | MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 35 MINUTES 02 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE | MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 52 MINUTES 54 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE |
| MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 35 MINUTES 02 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE | 36mg daily | MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 35 MINUTES 02 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE | MYMEMORY WARNING: YOU USED ALL AVAILABLE FREE TRANSLATIONS FOR TODAY. NEXT AVAILABLE IN 10 HOURS 52 MINUTES 54 SECONDS VISIT HTTPS://MYMEMORY.TRANSLATED.NET/DOC/USAGELIMITS.PHP TO TRANSLATE MORE |
Etkileşimler
Semaglutide
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Liraglutide
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Insulin
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Metformin
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BPC-157
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Yan Etkiler & Güvenlik
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